Bioenergetics 03 2024

General description

This block deals with energy metabolism in cells, and function of mitochondria.

Lectures
1. Structure and functions of mitochondria.
Dmytro GOSPODARYOV
  • Localization of mitochondria in the cell.
  • The structure of mitochondria.
  • Connection with the endoplasmic reticulum.
  • Features of mitochondrial DNA.
2. Forms of energy storage in the cell.
Andriy BABSKY
  • ATP as a universal source of energy.
  • Energetic and regulatory role of adenylate kinase and AMP-dependent kinase.
  • Other macroergic compounds.
  • Redox reactions in biological systems.
  • The role of pyridine and flavin nucleotides in redox reactions.
  • The role of mitochondria in "switching" from catabolism to anabolism and vice versa.
3. Energy sources in cells.
Andriy BABSKY
  • Glycolysis and energy metabolism.
  • Energetics of fat metabolism.
  • Catabolism of amino acids.
  • Role in the biological evolution, effectiveness and feasibility of use.
  • Krebs cycle.
  • Pyruvate dehydrogenase complex.
  • Energy-dependent reactions of the cycle.
  • Does the cycle always work "completely"?
  • "Amber" energy.
4. Structure and functions of the mitochondrial respiratory chain and ATP synthesis.
Andriy BABSKY
  • Proton gradient as a form of energy storage.
  • Theories of the coupling of respiration and oxidative phosphorylation.
  • Rotational catalysis of ATP synthesis.
  • The ratio between consumed O2 and synthesized ATP. R/O: 3 and 2,. or 2.5 and 1.5?
5. Mitochondria and active forms of oxygen.
Andriy BABSKY
  • Processes of lipid peroxidation and antioxidant protection of the cell.
  • Why do we age?
6. Transport systems of mitochondria.
Andriy BABSKY
  • Active and passive transport of substances through biological membranes.
  • What is the role of mitochondria in regulating the level of Ca2+ in the cell?
7. The role of mitochondria in physiological processes and pathologies.
Dmytro GOSPODARYOV
  • Physiology of muscles.
  • Secretion of insulin and hydrochloric acid.
  • Hereditary mitochondrial diseases.
  • schemia, diabetes, stroke, etc.
Seminars
1. Mitochondria and diseases: role of mitochondria in heart diseases, neurodegenerative diseases, autoimmune diseases.
Oksana IKKERT
2. Antioxidants in our life: aging, dermatology, food. Succinic bioenergetics: the role of succinate in medicine, food industry, sports. Is succinate doping or not?
Oksana IKKERT
3. Methods of studying mitochondrial respiration. Polarography; mitochondrial functional states. Various experimental protocols for assessing the mitochondria functional states.
Oksana IKKERT
Level
Bachelor and master students
Lectures
7 Lectures
Practical classes
3 Lesson
Duration
3 Months
Language
Ukrainian
Certificate
as part of the course
Lecturers
Андрій Бабський

Andriy Babsky

Head of the Department of Biophysics and Bioinformatics, professor of the Department of Human and Animal Physiology Ivan Franko National University of Lviv.

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Dmytro Gospodaryov

Associate Professor of the Department of Biochemistry and Biotechnology at the Vasyl Stefanyk Precarpathian National University.

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Oksana Ikkert

Oksana Ikkert

Associate Professor of the Department of Human and Animal Physiology Ivan Franko National University of Lviv

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